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This medicine is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder (social phobia), and a severe form of premenstrual syndrome called premenstrual dysphoric disorder (PMDD).
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Generic pill for zoloft, which had already been tested in Europe prior to Food and Drug Administration approval, will be available to treat depression, zoloft generic lupin bipolar disorder and other mood disorders in the United States within a year and half, pharmaceutical executive announced Monday at a conference hosted by the American Psychiatric Association.
A study published in February found that about 1 percent of adults in the U.S. have a form of depression that can be treated with an SSRI antidepressant. But those patients often are reluctant to try medications such as zoloft, a generic version of Prozac. And those symptoms depression can take months or even years for patients to treat, researchers at Johns Hopkins Bloomberg School of Public Health and Massachusetts General Hospital found.
"We're trying to develop a drug that we know works as well Prozac, but can be taken once, for a shorter time," said Dr. John Krystal, chief executive officer of the pharmaceutical company Amgen, which makes both drugs. "If done correctly, this pill could be a game-changer for depression."
Krystal said Amgen is moving forward with clinical trials on zoloft under a U.S. Food and Drug Administration-licensed company called AstraZeneca.
Dr. Paul Thompson, one zoloft 50 mg pill of the study's authors and a neurologist at Johns Hopkins who has used both drugs to treat people with severe depression, said the new drugs are both "more robust" and "better tolerated than the current medications."
Amgen said the new pills will be available in late summer. The FDA said it had approval to start human clinical trials in April.
Thompson has used zoloft for more than a decade. When he started taking it, said, "I thought it was going to do all I needed it to, which is to alleviate my distress."
Last winter, when he was preparing to begin a new job, his symptoms flared up. He suffered insomnia and suicidal thoughts and, on three different days, tried to jump out of his second floor office window. He sought out a psychiatrist, who prescribed cocktail of prescription drugs to calm his restless mind, but it didn't stop the cycle of depression.
"Every two weeks, I thought it would work," he said. "I didn't want to give up."
His psychiatrist sent him to AstraZeneca for an antidepressant that had previously been tested in Europe and proved equally effective for zoloft. But Thompson said zoloft 25 mg generic he was wary of taking another generic Prozac because it has a high rate of side effects, including weight gain and breast tenderness. He also didn't want to use pills because he was worried them might come with many unwanted side effects, and he wanted them to be as safe possible.
Krystal said an earlier version of zoloft that AstraZeneca developed to help patients better tolerate it wasn't well-liked by some and didn't fare very well in clinical trials. Amgen bought the rights to develop drug for patients who had been prescribed the older formulation, which was discontinued from the market in 2009.
Thompson said he was pleased to hear about the new drug but skeptical.
"It's a pretty good start," he said. "I am curious to see if they can overcome the side effects of medication.
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